悠洋棋牌

發布時間:2019-06-26         浏覽次數:10


怡 博士,副教授

郵箱:tjlinyi@xmu.edu.cn

電話:13950182657


學習經曆

     2008/09~2011/06 華中科技大學同濟醫學院,勞動衛生與環境衛生學專業;醫學博士

2005/09~2008/06 華中科技大學同濟醫學院藥學院;藥物分析專業;理學碩士

2001/09~2005/06 福建醫科大學藥學院;藥學專業;理學學士

工作經曆

2018/10~至今,廈門大學,公共衛生學院,副教授

2014/01~2018/09,中國科學院城市環境研究所,城市生態健康與環境安全研究中心,副研究員

2011/07~2013/12,中國科學院城市環境研究所,城市生態健康與環境安全研究中心,助理研究員

研究興趣

1. 環境內分泌幹擾物誘導機體代謝紊亂的毒性效應和分子機理。

2. 慢性代謝疾病(2型糖尿病、脂肪肝、肥胖、腫瘤等)的表觀遺傳調控機制。

3. 新興環境汙染物(微塑料、大氣顆粒物等)的分子毒理。

代表性論著*通訊作者,?第一作者)

  1. Yulang Chi?, Hongou Wang?Yi Lin*,Yanyang Lu, Qiansheng Huang, Guozhu Ye, Sijun Dong*. Gut microbiota characterization and lipid metabolism disorder found in PCB77-treated female mice. Toxicology, 2019, 420:11–20.

  2. Yulang Chi?, Yi Lin?, Huimin Zhu, Qiansheng Huang, Guozhu Ye, Sijun Dong. PCBs–high-fat diet interactions as mediators of gut microbiota dysbiosis and abdominal fat accumulation in female mice. Environ Pollut, 2018, 239: 332-341.

  3. Yanyang Lu?, Yi Lin?,*, Dongxiao Ding, Shu Su, Qiaoqiao Chi, Youchi Zhang, Jian Sun, Xu Zhang, Huimin Zhu, Qiansheng Huang, Yulang Chi, Guozhu Ye , Shu Tao, Sijun Dong*. MiR-26a Functions as a Tumor Suppressor in Ambient Particulate Matter-bound Metals-triggered Lung Cancer Cell Metastasis by targeting LIN28B-IL6-STAT3 axis. Arch Toxicol, 2018, 92:1023-1035.

  4. Jie Wei*, Dongxiao Ding, Tao Wang, Qiong Liu,Yi Lin*. MiR-338 controls BPA-triggered pancreatic islets insulin secretory dysfunction from compensation to decompensation by targeting Pdx-1. FASEB J, 2017, 31:5184-5195.

  5. Yi Lin?, Dongxiao Ding?, Qiansheng Huang, Qiong Liu, Haoyang Lu, Yanyang Lu,Yulang Chi, Xia Sun, Guozhu Ye, Huimin Zhu, Jie Wei*, Sijun Dong*. Downregulation of miR-192 Causes Hepatic Steatosis and Lipid Accumulation by Inducing SREBF1: Novel Mechanism for Bisphenol A-triggered Non-alcoholic Fatty Liver Disease. BBA-Mol Cell Biol L, 2017, 1862:869-882.

  6. Yanyang Lu?, Yi Lin?, Han Zhang, Dongxiao Ding, Xia Sun, Qiansheng Huang, Lifeng Lin, Ya-Jie Chen, Yu-Lang Chi, Sijun Dong*. Evaluation of Volatile Organic Compounds and Carbonyl compounds Present in Cabins of the Newly Produced, Medium- and Large-size Coaches in China. Int J Environ Res Public Health, 2016, 13: E596.

  7. Yi Lin, Lingli Min, Qiansheng Huang, Yajie Chen, Chao Fang, Xia Sun, Sijun Dong*. The combined effects of DEHP and PCBs on phospholipase in the livers of mice. Environ Toxicol, 2015, 30:197-204.

  8. Xia Sun?, Yi Lin?, Qiansheng Huang, Junpeng Shi, Ling Qiu, Mei Kang, Yajie Chen, Chao Fang, Ting Ye, Sijun Dong*. Di(2-ethylhexyl) Phthalate Induced INS-1 Cells Apoptosis is Dependent on Activation of Endoplasmic Reticulum Stress and Suppression of Antioxidant Protection. J Cell Mol Med, 2015, 19: 581-594.

  9. Jie Wei?, Xia Sun?, Yajie Chen, Yuanyuan Li, Liqiong Song, Zhao Zhou, Bing Xu, Yi Lin*, Shunqing Xu*. Perinatal exposure to bisphenol A exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet. J Endocrinol, 2014, 22: 313-325.

  10. Yi Lin?, Xia Sun?, Qiu Ling, Wei Jie, Huang Qiansheng, Fang Chao, Ye Ting, Kang Mei, Shen Heqing, Dong Sijun*. Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells. Cell Death Dis, 2013, 4: e460.

  11. Yi Lin?, Jie Wei?, Yuanyuan Li, Jun Chen, Zhao Zhou, Liqiong Song, Zhengzheng Wei, Ziquan Lv, Xi Chen, Wei Xia, and Shunqing Xu*. Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat. Am J Physiol Endocrinol Metab, 2011, 301:E527-38.

  12. Jie Wei?,Yi Lin?, Yuanyuan Li, Chenjiang Ying, Jun Chen, Liqiong Song, Zhao Zhou, Ziquan Lv, Wei Xia, Xi Chen, and Shunqing Xu*. Perinatal exposure to bisphenol A at reference dose predisposes offspring to metabolic syndrome in adult rats on a high-fat diet. Endocrinology, 2011, 152:3049-61.

  13. Yi Lin, Yun Shi, Ming Jiang, Yuan Jin, Yan Peng, Bin Lu*, Kang Dai. Removal of phenolic estrogen pollutants from different sources of water using molecularly imprinted polymeric microspheres. Environ Pollut, 2008, 153: 483-491.

  14. 孫霞,悠洋棋牌*,董四君*. 鄰苯二甲酸二(2-乙基)己酯暴露與糖代謝紊亂相關性的研究進展, 生態毒理學報, 2014, 9(3): 413-419.

承担的科研項目

  1. 國家自然科學基金面上項目,21677140,基于microRNA探討雙酚A致肝髒糖脂代謝紊亂的分子機制及父系傳代效應,66萬元,2017/01~2020/12

  2. 廈門大學校長基金項目,不同粒徑微塑料誘導肝髒糖脂代謝紊亂的毒性效應和分子機理研究,2072019008175萬元,2019/01~2021/12

  3. 福建省自然科學基金面上項目,2017J01028,雙酚A通過microRNA誘發非酒精性脂肪肝疾病發生發展的分子機制探討,4萬元,2017/04~2020/03

  4. 中國科學院青年創新促進會項目,201734980萬元,2017/01~2020/12

  5. 中國科學院城市環境研究所青年人才領不同粒徑微塑料誘導肝髒糖脂代謝紊亂的毒性效應和分子機理研究域前沿項目,IUEQN201506,微塑料及其負載的典型汙染物誘導機體代謝紊亂的風險和機制研究,30萬元,2016/01~2017/12

  6. 國家自然科學基金青年科學基金項目,21207128,新生期DEHP暴露誘導大鼠胰島β細胞損傷的分子機制研究,25萬元,2013/01~2015/12

  7. 福建省自然科學基金青年科學基金項目,2013J05033,雙酚A誘導胰島細胞氧化損傷的機制研究,3萬元,2013/01~2015/12

  8. 中國科學院城市環境研究所青年人才領域前沿項目,IUEQN201301,慢性PM2.5暴露對機體內源性代謝物的影響及其誘發代謝紊亂相關疾病的風險研究,40萬元,2013/09~2016/08

  9. 甯波市自然科學基金項目,2014A610274miRNA-192-5pPM2.5暴露誘導肝細胞脂肪變性中的作用及機制研究,3萬元,2014/02~2017/03