悠洋棋牌

發布時間:2019-03-15         浏覽次數:322


悠洋棋牌,廈門大學,公共衛生學院,副教授


病毒-宿主相互作用研究組組長國家傳染病診斷試劑與疫苗工程技術研究中心(NIDVD)分子疫苗學與分子診斷學國家重點實驗室(SKLVD)



教育經曆:

  1.  1. 2004/9–2012/6, 廈門大學, 生物化学与分子生物学, 博士

  2.  2. 2000/9–2004/6, 廈門大學, 生物学, 学士


科研與學術工作經曆:

  1.  2016/8-至今,廈門大學,公共衛生學院,副教授

  2.  2012/7-2016/7,廈門大學,公共衛生學院,助理教授

  3.  2008-至今,廈門大學NIDVD,病毒-宿主相互作用研究組組長


現階段主要研究興趣:

  1. 病毒、疫苗誘導的宿主B細胞(抗體)免疫應答研究(戊型肝炎病毒、乙型肝炎病毒、流感病毒、呼吸道合胞病毒)

  2. 病毒受體、感染機制及免疫逃逸機制研究(戊型肝炎病毒、呼吸道合胞病毒)

  3. 戊型肝炎臨床新特征及肝外感染症狀研究

  4. 呼吸道合胞病毒(致兒童肺炎)預防及治療性疫苗、藥物研發

  5. 腫瘤組織浸潤性B細胞研究


部分代表性論文:

  1.  Chang Liu, Wei Cai, Xin Yin, Zimin Tang, Guiping Wen, Charuta Ambardekar, Xinlei Li, Dong Ying, Zongdi Feng*, Zizheng Zheng*, Ningshao Xia, An Optimized High-Throughput Neutralization Assay for Hepatitis E Virus (HEV) Involving Detection of Secreted Porf2, Viruses, 2019, 11(1) (Co-Corresponding author)

  2.  Xue Liu#, Chao Liu#, Zizheng Zheng#, Siyuan Chen, Xin Pang, Xinchu Xiang, Jixian Tang, En Ren, Yuanzhi Chen, Min You, Xiaoyong Wang, Xiaoyuan Chen, Wenxin Luo,* Gang Liu,* and Ningshao Xia*. Vesicular Antibodies: A Bioactive Multifunctional Combination Platform for Targeted Therapeutic Delivery and Cancer Immunotherapy. Advanced Materials, 2019, (Accepted, Co-First author)

  3.  Si-Ling Wang, Birendra Prasad Gupta, Wen-Fang Ji, Zi-Min Tang, Gui-Ping Wen, Anurag Adhikari, Dong Ying, Xu Zhang, Chang Liu, Zi-Zheng Zheng*, Ning-Shao Xia. Application of Hepatitis E Virus-Related Markers on Samples from a Developing Country. Clin. Lab. 2019;65:235-241 (Corresponding author)

  4.  Xin Yin, Dong Ying, Sébastien Lhomme, Zimin Tang, Christopher M. Walker, Ningshao Xia, Zizheng Zheng*, Zongdi Feng*, Origin, antigenicity, and function of a secreted form of ORF2 in hepatitis E virus infection, Proceedings of the National Academy of Sciences of USA, 2018, 115(18): 4773-4778 (Co-Corresponding author)

  5.  Guiping Wen, Changrong Chen, Xiuyu Song, Zimin Tang, Wenfang Ji, Siling Wang, Ke Zhang, Jun Zhang, Shanhai Ou*, Zizheng Zheng*, Ningshao Xia, Long-term HEV carriers without antibody seroconversion among eligible immunocompetent blood donors, Emerging Microbes & Infecttions, 2018, 7(1): 125 (Co-Corresponding author)

  6.  Min Zhao#, Zi-Zheng Zheng#, Man Chen, Kayvon Modjarrad, Wei Zhang, Lu-Ting Zhan, Jian-Li Cao, Yong-Peng Sun, Jason S. McLellan, Barney S. Graham*, Ning-Shao Xia*, Discovery of prefusion respiratory syncytial virus F-specific monoclonal antibody that provides greater in vivo protection than the murine precursor of Palivizumab, Journal of Virology, 2017, 91(15): 1-17 (Co-First author)

  7. Tian, Daiyin#; Battles, Michael B.#; Moin, Syed M.; Chen, Man; Modjarrad, Kayvon; Kumar, Azad; Kanekiyo, Masaru; Graepel, Kevin W.; Taher, Noor M.; Hotard, Anne L.; Moore, Martin L.; Zhao, Min; Zheng, Zi-Zheng; Xia, Ning-Shao*; McLellan, Jason S.*; Graham, Barney S*. Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibodytargeting the fusion glycoprotein, Nature Communications, 2017.11.30, 8: 1~7

  8. Wen, Gui-Ping#; Tang, Zi-Min#; Wang, Si-Ling; Ji, Wen-Fang; Cai, Wei; Zhang, Xu; Huang, Shou-Jie; Wu, Ting; Zhang, Jun; Zheng, Zi-Zheng*; Xia, Ning-Shao*, Classification of human and zoonotic group hepatitis E virus (HEV) using antigen detection, Applied Microbiology and Biotechnology, 2017.12, 101(23-24): 8585~8594(Co-Corresponding author)

  9. Cai, Wei#; Tang, Zi-Min#; Wen, Gui-Ping; Wang, Si-Ling; Ji, Wen-Fang; Yang, Min; Ying, Dong; Zheng, Zi-Zheng*; Xia, Ning-Shao*. A high-throughput neutralizing assay for antibodies and sera against hepatitis E virus, Scientific Reports, 2016.4.28, 6: 1~8(Co-Corresponding author)

  10. Tang, Zi-Min; Wang, Si-Ling; Ying, Dong; Wen, Gui-Ping; Cai, Wei; Zhang, Ke; Ji, Wen-Fang; Yang, Ming; Zheng, Zi-Zheng*; Xia, Ning-Shao*. The Bama miniature swine is susceptible to experimental HEV infection, Scientific Reports, 2016.8.18, 6: 1~6(Co-Corresponding author)

  11. Wen, Gui-Ping#; Tang, Zi-Min#; Yang, Fan; Zhang, Ke; Ji, Wen-Fang; Cai, Wei; Huang, Shou-Jie; Wu, Ting; Zhang, Jun; Zheng, Zi-Zheng*; Xia, Ning-Shao*. A valuable antigen detection method for diagnosis of acute hepatitis e. Journal of Clinical Microbiology, 2015.3.01, 53(3): 782~788(Co-Corresponding author)

  12.  Min Zhao#, Xiao-Jing Li#, Zi-Min Tang, Fan Yang, Si-Ling Wang, Wei Cai, Ke Zhang, Ning-Shao Xia*, Zi-Zheng Zheng*, A comprehensive study of neutralizing antigenic sites on the hepatitis E virus (HEV) capsid by constructing, clustering and characterizing a tool box, Journal of Biological Chemistry, 2015, 290(32): 19910-19922 (Co-Corresponding author)

  13.  Tang, Zi-Min#; Tang, Ming#; Zhao, Min; Wen, Gui-Ping; Yang, Fan; Cai, Wei; Wang, Si-Ling; Zheng, Zi-Zheng*; Xia, Ning-Shao*. A novel linear neutralizing epitope of hepatitis E virus. Vaccine, 2015.7.9, 33(30): 3504~3511 (Co-Corresponding author)

  14.  McLellan, Jason S ; Chen, Man; Leung, Sherman; Graepel, Kevin W; Du, Xiulian; Yang, Yongping; Zhou, Tongqing; Baxa, Ulrich; Yasuda, Etsuko;Beaumont, Tim; Kumar, Azad; Modjarrad, Kayvon; Zheng, Zizheng; Zhao, Min; Xia, Ningshao; Kwong, Peter D ; Graham, Barney SStructure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science, 2013.5.31, 340(6136): 1113~1117

  15.  McLellan, Jason S; Chen, Man; Joyce, M Gordon; Sastry, Mallika; Stewart-Jones, Guillaume B E; Yang, Yongping; Zhang, Baoshan; Chen, Lei; Srivatsan, Sanjay; Zheng, Anqi; Zhou, Tongqing; Graepel, Kevin W; Kumar, Azad; Moin, Syed; Boyington, Jeffrey C; Chuang, Gwo-Yu; Soto, Cinque; Baxa, Ulrich; Bakker, Arjen Q; Spits, Hergen; Beaumont, Tim; Zheng, Zizheng; Xia, Ningshao; Ko, Sung-Youl; Todd, John-Paul; Rao, Srinivas; Graham, Barney S ; Kwong, Peter D , Structure-based design of a fusion glycoprotein vaccine forrespiratory syncytial virus. Science, 2013.11.1, 342(6158): 592~598


授權發明專利

  1. 悠洋棋牌,賈森·麥克萊倫,陳曼,趙敏,黃粱敏,巴尼·格雷厄姆,夏甯邵,RSV融合蛋白的表位以及識別其的抗體, 2019.01.17,澳大利亞,2014231357

  2. 悠洋棋牌,賈森·麥克萊倫,陳曼,趙敏,黃粱敏,巴尼·格雷厄姆,夏甯邵,RSV融合蛋白的表位以及識別其的抗體, 2018.01.02,美國,US9856313B2

  3. 悠洋棋牌,唐自閩,趙敏,李曉靜,溫桂平,李婧娴,張軍,夏甯邵,特異結合戊型肝炎病毒34型的抗體及其用途, 2017.08.25,中國,ZL201310069913.4


主持或参加科研項目(部分):

 1. 國家自然科學基金面上項目,81871247,戊型肝炎病毒分泌型衣殼蛋白的結構與功能探究,2019/01-2022/12,主持

 2. 國家科技重大專項傳染病重大專項(2018ZX10101001-002),試劑的預認證和海外分子流行病學研究,2018/01-2020/12,主持

 3. 國家自然科學基金青年科學基金項目,8170061359,中和抗體對不同類型HEV的保護機制,2018/01-2020/12, 在研,參加、骨幹成員

 4. 福建省自然科學基金資助項目,2016J05201,戊型肝炎病毒基因型間宿主差異的分子機制研究,2016/04-2019/03已結題,主持

 5. 國家自然科學基金青年科學基金項目,81401668,抗呼吸道合胞病毒高中和活性抗體的保護機制研究,2015/01-2017/12,已結題,主持

 6. 國家自然科學基金國際(地區)合作與交流項目,81361120408,單克隆抗體中和呼吸道合胞病毒的結構基礎,2014/01-2016/12,已結題,参加、骨干成员

 7. 國家自然科學基金國際(地區)合作與交流項目,81161120419,中和呼吸道合胞病毒感染的分子結構基礎,2012/01-2012/12,已結題,参加、骨干成员



獲得學術獎勵

  1. 求是獎傑出科技成就集體獎, 2015

  2. 創新人才推進計劃重點領域創新團隊-疫苗與體外診斷創新團隊, 2013